The main disadvantage of cache miss in a distributed caching system for microservices is that it can decrease the performance of the system.

 This is because when a cache miss occurs, the data must be fetched from the original source, which can be slower than accessing it from the cache.

 As a result, cache miss can reduce the overall performance of the system by slowing down access to frequently used data. 

https://medium.datadriveninvestor.com/all-things-caching-use-cases-benefits-strategies-choosing-a-caching-technology-exploring-fa6c1f2e93aa